Detection of ADAR1 mRNA expression in larynx carcinoma tissues.
- Author:
Wenfa YU
1
;
Yulin ZHAO
;
Kai WANG
;
MingMin DONG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
- Publication Type:Journal Article
- MeSH:
Adenosine Deaminase;
genetics;
metabolism;
Aged;
Female;
Humans;
Laryngeal Neoplasms;
genetics;
metabolism;
pathology;
Male;
Middle Aged;
RNA, Messenger;
genetics;
RNA-Binding Proteins
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(2):73-75
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of RNA-dependent adenosine deaminase 1(ADAR1) mRNA in larynx carcinoma tissues, and to discuss its value in the development of larynx carcinoma.
METHOD:The expression of ADAR1 mRNA in 51 larynx carcinoma and peri-carcinoma tissues were detected by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR).
RESULT:ADAR1 mRNA was expressed broadly; the relative intensities of its expression in larynx carcinoma, larynx peri-carcinoma samples and larynx non-carcinoma tissue samples were respectively 2.963 +/- 0.912, 0.791 +/- 0.197 and 0.910 +/- 0.311. There were remarkable difference between larynx carcinoma and larynx peri-carcinoma, larynx carcinoma and non-carcinoma tissues.
CONCLUSION:ADAR1 mRNA is expressed broadly in larynx carcinoma and may be play an important role in the development of larynx carcinoma.
