Acute injury of inhalable particle matters on nasal mucous membrane of rat.
- Author:
Xiaoling LIU
1
;
Zhimin XING
;
Lisheng YU
;
Jianqiang DONG
;
Furong DENG
Author Information
1. Department of Otorhinolaryngology, Pepole's Hospital of Beijing University, Beijing, 100044, China.
- Publication Type:Journal Article
- MeSH:
Air Pollutants;
adverse effects;
Animals;
Inhalation;
Male;
Microscopy, Electron, Scanning;
Nasal Mucosa;
pathology;
ultrastructure;
Particulate Matter;
adverse effects;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(2):84-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mechanism of the nasal mucous membrane inflammation induced by the inhalable particle matter (PM10).
METHOD:Three dosage PM10 were instilled in rat nasal cavity of different groups for one week. The morphology of nasal mucosa and the numbers of inflammatory cell were observed in each samples.
RESULT:The total numbers of inflammatory cells in PM10-treated groups were increased in a dose-respondent manner and significantly different from that in control group. The results of histopathological and scanning electron microscope (SEM) analysis indicated that PM10 caused nasal mucosa injury and pathological changes, such as the damage of cilia and nasal mucosa epithelium in a dose dependent way. The infiltration of inflammatory cells in nasal mucosa epithelium matrix, especially eosinophilia were observed.
CONCLUSION:PM10 can cause rat's nasal mucosa inflammation and epithelial injury.
