Cytogenetic Analysis for Amenorrhea.
- Author:
Woo In LEE
1
;
Jin Tae SUH
;
Eun Hee CHOI
Author Information
1. Department of Clinical Pathology, Medical College of Kyung Hee University, Seoul, Korea
- Publication Type:Original Article
- Keywords:
Chromosome aberration;
Amenorrhea;
X chromosome
- MeSH:
Amenorrhea*;
Chromosome Aberrations;
Cytogenetic Analysis*;
Cytogenetics*;
Female;
Humans;
Incidence;
Lymphocytes;
Mass Screening;
Mosaicism;
X Chromosome;
Y Chromosome
- From:Korean Journal of Clinical Pathology
1999;19(6):741-745
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Chromosomal aberration is one of the major causes of amenorrhea. So we studied the incidence and the clinical importance of chromosomal aberration in patients with amenorrhea. METHODS: Cytogenetic investigations were carried out on 101 women with amenorrhea from Jan. 1990 to Dec. 1998. Peripheral blood lymphocytes were cultured for chromosomal studies by the standard method. RESULTS: In primary amenorrhea, 27 cases (38.6%) showed aberrations of chromosome. 45,X and their mosaicism were 14 cases (20.0%), structural anomalies of the X chromosome were 6 cases (8.6%) and the presence of Y chromosome, 5 cases (7.1%). In secondary amenorrhea, one case (3.2%) showed aberration of chromosome. CONCLUSIONS: The overall incidence of chromosomal aberration in amenorrhea was 27.7%. Cytogenetic screening is very important for the investigation of causes of the amenorrhea.
