Expression of tissue inhibitor of metalloproteinase-2 in nasopharyngeal carcinoma.
- Author:
Li YAO
1
;
Pingping LIU
;
Xing LU
;
Fengan LIU
Author Information
1. Department of Otolaryngology, Beijing University Shenzhen Hospital,Shenzhen, 518036, China. yllp20@tom.com
- Publication Type:Journal Article
- MeSH:
Adult;
Double-Blind Method;
Female;
Humans;
Male;
Matrix Metalloproteinase 2;
metabolism;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging;
Tissue Inhibitor of Metalloproteinase-2;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(18):831-833
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of tissue inhibitor of matrix metalloproteinase 2 (TIMP2)in the nasopharyngeal carcinoma and to evaluate the relationships between the expression of TIMP2 and biological behavior of NPC.
METHOD:The expression of TIMP2 was observed by immunohistochemical technique in 50 cases with nasopharyngeal carcinoma and 15 cases of Inflammation nasopharyngeal tissues.
RESULT:The positive rates of TIMP2 are significantly higher in NPC than in Inflammation tissues (P < 0.05). The expression of TIMP2 increase significantly with lymph node metastasis (P < 0.01), but had no relevant to the rise clinical invasion stage (P > 0.05).
CONCLUSION:The results indicate that TIMP2 may play a critical role in assisting carcinoma cell to degrade basement membrane to invade surrounding tissues and to form metastatic colonies in lymph node. Especially the unbalance in MMP2/TIMP2 has probably a prognostic value in nasopharyngeal carcinoma.
