The effect of VEGF and MVD in the formation of nasal polyps.
- Author:
Xiaofeng MA
1
;
Dong CHEN
;
Li CHAI
;
Jian KANG
Author Information
1. The First Affiliated Hospital of Liaoning Medical College, Jinzhou 120001, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Microvessels;
pathology;
Nasal Polyps;
metabolism;
pathology;
Neovascularization, Pathologic;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(23):1077-1079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of vascular endothelial growth factor(VEGF) and microvessel density (MVD), in nasal polyps and its significance.
METHOD:The expression of VEGF, in nasal polyps from 50 patients and inferior turbinates from 10 patients were studied with immunohistochemical methods, measuring their grey score, the relations between expression microvessel density were analyzed.
RESULT:(1) The differences between the VEGF expression in nasal polyp gland and vascular were significant (P < 0.05). (2) The differences between the microvessel quantities in nasal polyps and inferior turbinates were significant (P < 0.05). (3) The association between VEGF expression in vascular of nasal polyps and microvessel density was significant (r = -0.664 (< 0. 05).
CONCLUSION:In nasal polyps, VEGF, expression increased. Those results show that the abnormal expression of VEGF and MVD may play an impotent role in the development of nasal polyps. There was an important value for proper treatment and prediction of nasal polyps.
