The correlation between the expression of AQP1 and angiogenesis ability in nasopharyngeal carcinoma.
- Author:
Qi LI
1
;
Wei ZHANG
;
Bao ZHANG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Southern Medical University, Guangzhou, 510515, China. hxllq@126.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aquaporin 1;
metabolism;
Female;
Humans;
Male;
Microvessels;
pathology;
Middle Aged;
Nasopharyngeal Neoplasms;
blood supply;
metabolism;
pathology;
Neovascularization, Pathologic;
Vascular Endothelial Growth Factor A;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(24):1115-1118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and correlation of Aquaporin-1 (AQP1), VEGF and MVD in nasopharyngeal tumor and non-tumor tissues.
METHOD:Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative PCR (RT-PCR) to detect the expression level of AQP1 and VEGF in tissues. MVD were then calculated.
RESULT:Both immunohistochemistry and RT-PCR showed higher expression of AQP1 and VEGF in tumor tissues than in non-tumor tissues. The two factors were positively correlated.
CONCLUSION:In nasopharyngeal carcinoma, AQP1 may participate in angiogenesis by VEGF. Thus it may facilitate the tumor's growing and metastasis.
