A clinical study on changes of EGF in serum before and after endoscopic surgery in patients with chronic sinusitis disease.
- Author:
Pengju WANG
1
;
Yin SHEN
Author Information
1. Department of Otolaryngology, the Centrol Hospital of Xiangyang, Xiangyang, 441021, China. wangpju@sohu.com
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Chronic Disease;
Endoscopy;
Epidermal Growth Factor;
blood;
Female;
Humans;
Male;
Middle Aged;
Sinusitis;
blood;
surgery;
Treatment Outcome;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(2):49-50
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the changes of epidermal growth factor (EGF) in serum before and after endoscopic surgery in patients with chronic sinusitis, and then to explore its clinical significance.
METHOD:Serum was collected before and after operation and EGF concentrations were measured by the radioimmunoassay at different times.
RESULT:EGF levels in patients with chronic sinusitis (1.24 +/- 0.41) microg/L were higher than that in control group (0.92 +/- 0.23) microg/L, but there were no significantly difference between them (P > 0.05). The concentrations of EGF were reduced after surgery, and the lowest were evaluated after 4 weeks. Significant difference of EGF concentrations were found between before and 4 weeks after operation (P < 0.01). The concentration of EGF were raised 6 weeks after surgery, and returned to normal after 8 weeks.
CONCLUSION:The changes of EGF in serum before and after endoscopic surgery may relate with the epithelization process of sinus mucosa after endoscopic surgery.
