Clinical study on cytokine induced killer cells therapy to laryngeal cancer after radiotherapy.
- Author:
Shiwen ZHANG
1
;
Xiaoguang HE
;
Xiaojiang LI
;
Yanxin REN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Kunming College, Kunming, 650118, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Carcinoma, Squamous Cell;
immunology;
pathology;
radiotherapy;
Combined Modality Therapy;
Cytokine-Induced Killer Cells;
immunology;
Humans;
Immunotherapy, Adoptive;
Killer Cells, Natural;
immunology;
Laryngeal Neoplasms;
immunology;
pathology;
radiotherapy;
Male;
Middle Aged;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(2):61-63
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the immunity changes of patients after CIK cells being transfused back, and then to discuss the effects of CIK cells on curing laryngeal cancers.
METHOD:Forty eight laryngeal cancer patients with low immune function were collected. The immunity index in the peripheral blood of patients before/after radiotherapy and after CIK cells therapy were measured and compared with normal one.
RESULT:After radiotherapy, the percentage of CD3+, CD4+ cells declined, the percentage of CD8+ cells increased; the rate of CD4+ /CD8+ declined and the rate of Th1/Th2 reversed. There were no significant difference between the immunity indexes before and after radiotherapy (P < 0.05). After CIK cell therapy, the above indexes were improved (P < 0.05), but the values didn't returned to normal. After radiotherapy and after CIK therapy, the value of B cell didn't changed obviously (P > 0.05), while the percentage of NK cells changed obviously (P < 0.05).
CONCLUSION:Radiotherapy can restrain the immune function of the patients with laryngeal cancers. CIK therapy is safe and might improve the recent immune function of the patients.