Expression of C-erbB-2 and EGFR expression and its relationship with cell proliferation in nasopharyngeal carcinoma.
- Author:
Yan ZHANG
1
;
Gengtian LIANG
;
Guangbin SUN
;
Zhaohu PAN
;
Guomin WU
;
Zheng LIU
Author Information
1. Department of Pathology, Taizhou Hospital of Zhejiang Province, Linhai, 317000, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cell Proliferation;
ErbB Receptors;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Proliferating Cell Nuclear Antigen;
metabolism;
Receptor, ErbB-2;
metabolism;
Respiratory Mucosa;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(2):67-70
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of epidermal growth factor receptor (EGFR), C-erbB-2 and its relationship with cell proliferation in nasopharyngeal carcinoma.
METHOD:Expression of C-erbB-2, EGFR and proliferating cell nuclear antigen (PCNA) were detected with immunohistochemical staining in 32 nasopharyngeal carcinoma samples and 12 chronic inflammatory nasopharyngeal tissue samples.
RESULT:The positive rate of EGFR,C-erbB-2, and PCNA expression in nasopharyngeal carcinoma was 65.6%, 37.5%, and (42.5 +/- 22.6)%, respectively, which was significantly higher than that in chronic inflammatory nasopharyngeal tissue (P < 0.05). There were positive correlations between the positive rate of EGFR, C-erbB-2, and PCNA expression and histopathological stage. The co-expression of C-erbB2 and EGFR was found in 62.5% (20/32) nasopharyngeal carcinoma samples. There was a positive correlation between C-erbB-2 and EGFR expression (r = 0.38, P < 0.05). The highest percentage of PCNA expression was found in carcinoma samples with co-expression of C-erbB and EGFR.
CONCLUSION:C-erbB-2, EGFR might have synergetic effect in the development and progress of nasopharyngeal carcinoma. The co-expression of C-erbB-2 and EGFR closely correlates with cell proliferation status.
