Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma.
- Author:
Yanqiu CHEN
1
;
Yan YANG
;
Zhibin LIN
;
Hua PENG
;
Hangui LU
Author Information
1. Guangzhou Women and Children's Medical Center, Guangzhou, 510080, China. frankcyq2002@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cell Cycle Proteins;
metabolism;
Female;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging;
Nuclear Proteins;
metabolism;
Prognosis;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(2):71-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of human nuclear distribution (hNudC) in nasopharyngeal carcinoma (NPC).
METHOD:Immunohistochemical and western blot method were used to determine the expression of human nuclear distribution C in 80 cases of NPC and 30 cases of chronic inflammation of nasopharyngeal mucosa. The amounts of positive cells were analyzed . The relationship between the gene expression and clinic pathological features was analyzed too.
RESULT:The positive expression rate of human nuclear distribution C in NPC was 83.75%, which was higher than that in chronic inflammation of nasopharyngeal mucosa 23.33% (P < 0.05). The expression of human nuclear distribution C was positively correlated with the clinic pathological stages in NPC (P < 0.05), and positive expression rate of hNudC protein was increased with the progress of NPC clinical stage (P < 0.05).
CONCLUSION:Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia. This protein is important indicators to predict the progression of patients.
