Analysis on expression of survivin and PTEN in vocal cords polyps, papilloma of larynx and laryngeal squamous cell carcinoma.
- Author:
Qiangzhong GUO
1
;
Yunying LI
Author Information
1. Department of Otolaryngology, Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 510120, Guangzhou, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Humans;
Inhibitor of Apoptosis Proteins;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Middle Aged;
PTEN Phosphohydrolase;
metabolism;
Polyps;
metabolism;
pathology;
Survivin;
Vocal Cords;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(15):704-707
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Through exploring the differentiation on positive expressing rates between oncogene survivin and tumor-suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome ten) on vocal cord polyps (VCP), adult type laryngeal papilloma (ALP), and laryngeal squamous cell carcinoma (LSCC), to reveal the mechanism in cancellation of human laryngeal squamous cells, from benign proliferative lesion, benign tumor to malignant tumor in larynx.
METHOD:After picking out 18 cases of VCP, 10 cases of ALP, and 18 cases of LSCC for immunohistochemical process of Survivin and PTEN with two continuous section preparations, the differentiations of positive expression rates of Survivin and PTEN in the same human laryngeal squamous cells areas among three diseases were compared.
RESULT:The positive expressing rates of survivin and PTEN in VCP were obviously more lower than in ALP and LSCC (P < 0.05), which showed no obvious difference between each other(P > 0.05). The positive expressing rates of survivin were always higher than PTEN in VCP, ALP and LSCC evidently (P < 0.05).
CONCLUSION:PTEN, expressing for competition purpose, shows a subordinative relationship with Survivin. Although they have opposite functions in determine whether the cancellation of laryngeal squamous cells take place or not, Survivin is always playing the leading role and making predominant impact on development of benign proliferative lesion, benign and malignant tumor in larynx.
