Present research on the status and the prospect of insulin-like growth factor-I in head and neck cancer.
- Author:
Xiuhong LIU
;
Lixin JIANG
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cell Movement;
Cell Proliferation;
Head and Neck Neoplasms;
metabolism;
pathology;
Humans;
Insulin-Like Growth Factor I;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(15):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factor-I (IGF-I) is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF- I and its regulatory factors, the molecular biological role of IGF- I in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-I in head and neck tumor, as well as put forward the prospects of IGF-I in middle ear cholesteatoma pathogenesis.
