The study of the correlation of papillary thyroid carcinoma's invasion toward Ezrin and E-cadherin.
- Author:
Chang LIU
1
;
Xi CHEN
;
Zhengnan GAO
;
Zhong LIU
;
Xiaofeng TAO
Author Information
1. Department of Endocrinology, Dalian Central Hospital, Dalian, 116033, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antigens, CD;
Cadherins;
metabolism;
Carcinoma;
metabolism;
pathology;
Carcinoma, Papillary;
Cytoskeletal Proteins;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Prognosis;
Thyroid Cancer, Papillary;
Thyroid Neoplasms;
metabolism;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(17):789-795
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:In order to assess the significance of Ezrin and E-Cadherin in invasion and metastasis of papillary thyroid carcinoma (PTC).
METHOD:The 81 paraffin-embedded specimen PTC and normal thyroid tissues adjacent to cancer operated from 2005 to 2008 were tested. The expressions of Ezrin, E-Cadherin in the specimen were assayed by immunohistochemical staining. The correlation between the 2 factors (Ezrin, E-Cadherin) and clinical features of PTC such as gender, age, tumor size, invasion, lymph node metastasis, and TNM stage were studied.
RESULTS:The rates of immuno-positive staining Ezrin in PTC was higher than the normal thyroid tissues adjacent to cancer with significant difference respectively (chi2 = 61.691, P < 0.01). The rates of immuno-positive staining E-Cadherin in PTC was lower than the normal thyroid tissues adjacent to cancer with significant difference respectively (chi2 = 64.241, P < 0.01). The expressions of Ezrin and E-cadherin were related to age, invasion, lymph node metastasis, and TNM. There was correlation between the expressions of Ezrin and E-Cadherin in PTC (r = -0.471, P < 0.01).
CONCLUSION:The high expressions of Ezrin and the low expression of E-Cadherin were related to invasion and metastasis in PTC. Between the 2 factors has cooperative. Combined detection of the expression of Ezrin and E-Cadherin in PTC might served as invasion, metastasis and important prognostic predictors.
