Comparative study of IL-4, IFN-gamma gene methylation for the epigenetics of allergic rhinitis in Xinjiang Uygur, Han people.
- Author:
Zhongzhang LOU
1
;
Huiwu WANG
;
Qing YANG
;
Xiaofang JIANG
;
Qingquan ZHANG
;
Ni Re MU
;
He Ta Er MU
;
Li GAO
Author Information
1. Department of Otorhinolaryngology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 230001, China.
- Publication Type:Journal Article
- MeSH:
Adult;
China;
epidemiology;
DNA Methylation;
Epigenesis, Genetic;
Ethnic Groups;
genetics;
Female;
Gene Frequency;
Humans;
Interferon-gamma;
genetics;
Interleukin-4;
genetics;
Male;
Promoter Regions, Genetic;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
epidemiology;
genetics
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(18):795-797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the differences of IL-4, IFN-gamma gene promoter methylation of allergic rhinitis patients between Uygur and Han people of Xinjiang.
METHOD:Methylation-specific PCR (MSP) detected IL-4, IFN-gamma gene methylation of each of 50 patients with allergic rhinitis in Uygur and Han.
RESULT:Complete IL-4 gene promoter methylation rate was 44% (22/50) and 48% (24/50) in Uygur and Han AR patients, un-methylation was 26% (13/50) and 22% (11/50), coexistence rate of methylation and un-methylation was 30% (15/50) and 30% (15/50). Complete IFN-gamma gene promoter methylation rate was 12% (6/50) and 16% (8/50) in Uygur and Han AR patients, un-methylation was 8% (4/50) and 10% (5/50), coexistence rate of methylation and unmethylated was 80% (40/50) and 74% (37/50). Distribution of IL-4 gene methylation between Han and Uygur AR patients had no statistically significant (P > 0.05). Distribution of IFN-gamma gene methylation between Han and Uygur AR patients had no statistically significant (P > 0.05).
CONCLUSION:There is no difference of IL-4, IFN-gamma gene methylation in patients between the Han and Uygur.
