Efficacy and safety of sublingual immunotherapy with house dust mite extract in poly allergen sensitized children with allergic rhinitis.
- Author:
Lifeng ZHOU
1
;
Jie WANG
;
Yanqiu CHEN
;
Renzhong LUO
;
Jia TAO
;
Mingrong NIE
;
Bixia LIU
;
Yuyun LI
Author Information
1. Department of Otolaryngology,Guangzhou Women and Children Medical Central, Guangzhou, 510623, China.
- Publication Type:Journal Article
- MeSH:
Administration, Sublingual;
Adolescent;
Animals;
Antigens, Dermatophagoides;
administration & dosage;
immunology;
therapeutic use;
Asthma;
therapy;
Child;
Child, Preschool;
Dermatophagoides farinae;
immunology;
Desensitization, Immunologic;
Female;
Humans;
Immunotherapy;
Male;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(20):913-916
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the efficacy of sublingual immunotherapy (SLIT) with standardized house dust mite extract in mono sensitized and polysensitized children with allergic rhinitis.
METHOD:One hundred and fifty-seven children who were sensitized to house dust mites and treated with SLIT for house dust mites for at least 1 year were studied. The monoallergen sensitized group included patients who were sensitized to Dermatophagoides pteronyssinus and/or Dermatophagoides farinae (n=92). The polyallergen sensitized group included patients who were simultaneously sensitized to house dust mites and other allergens (n = 65). A standardized extract of house dust mites was used for immunotherapy. Antiallergic medication and the total nasal symptom score (TNSS) were evaluated before and 1 year after SLIT.
RESULT:One hundred and twenty-five children completed 1-year SLIT. The TNSS improved significantly after SLIT in both groups, with monoallergen sensitized group 11.42 +/- 1.60 vs 3.55 +/- 1.57 (t=30.03, P<0.01), and polyallergen sensitized group 11.54 +/- 1.55 vs 3.23 +/- 1.56 (t=27.76, P< 0.01). But the change in the TNSS did not differ significantly between the groups (TNSS change, 7.94 +/- 2.24 vs 8.32 +/- 2.18, P>0.05). The AMSs were decreased significantly after SLIT in both groups, with monoallergen sensitized group 1.62 +/- 0.44 vs 0.56 +/- 0.37 (t=15.01, P<0.01), and polyallergen sensitized group 1.63 +/- 0.43 vs 0.50 +/- 0.40 (t=13.49, P<0.01). But the AMSs improvement did not differ significantly between the two groups(AMSs change 1.03 +/- 0.58 vs 1.13 +/- 0.61, P>0.05).
CONCLUSION:In polysensitized allergic rhinitis patients, SLIT for D pteronyssinus and/or D farinae produced improvements in both nasal symptoms and rescue medication scores comparable to those in mono sensitized patients. SLIT for D pteronyssinus and/or D farinae should be considered in polysensitized allergic rhinitis patients.
