Effects of tripterine on NF-kappaB and eotaxin in nasal mucosa of allergic rhinitis rat.
- Author:
Ying LI
1
;
Xiangdong CHEN
Author Information
1. Department of Otolaryngology, the Affiliated Hospital of Zhengzhou University, Central Hospital of Zhengzhou, Zhengzhou, 450007, China. ikkoi@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Chemokine CCL11;
metabolism;
NF-kappa B;
metabolism;
Nasal Mucosa;
drug effects;
metabolism;
Rats;
Rats, Sprague-Dawley;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
metabolism;
Triterpenes;
pharmacology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(20):943-945
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship among the expressions of NF-kappaB, Eotaxin and the effects of tripterine in nasal mucosa of allergic rhinitis rat and to discuss the possible mechanism of tripterine on allergic rhinitis.
METHOD:Forty healthy SD rats were randomly divided into four groups: OVA group,tripterine group (T group), DM group, and SC group. Allergic rhinitis model was established by OVA. The pathological changes were observed by HE staining. The expressions of NF-kappaB and Eotaxin were examined by SP immunohistochemical analysis.
RESULT:There was no pathological change in SC group. Nasal mucosa in T and DM group was swelling,and there were some inflammatory cells. Nasal mucosa in OVA group was highly swelling, and there were abundant inflammatory cells. NF-kappaB and Eotaxin expression in OVA group was significantly different from the other three groups (P<0.01). And no difference was observed between T and DM groups (P>0.05). The expression of NF-kappaB in OVA group had positive correlation with the expression of Eotaxin (r=0.908, P<0.01).
CONCLUSION:Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB.
