Expression of Th17 related cell factors and its significance in CRSsNP.
- Author:
Baofeng WANG
1
;
Bennong LI
;
Jing CAO
;
Hongyu ZHOU
;
Yanni LI
Author Information
1. Department of Otorhinolaryngology, Puai Hospital, Wuhan,430034, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Chronic Disease;
Female;
Humans;
Interleukin-17;
immunology;
Interleukins;
immunology;
Male;
Middle Aged;
Neutrophil Infiltration;
Neutrophils;
immunology;
Nuclear Receptor Subfamily 1, Group F, Member 3;
immunology;
Sinusitis;
immunology;
Th17 Cells;
immunology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(20):946-948
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of Th17 nuclear factor RORC and cytokines IL-17A and IL-22 and neutrophil marker MPO and their correlations with CRSsNP.
METHOD:RT-PCR was used to detect mRNA expression of RORC, IL-17A and IL-22. Immunohistochemistry was used to assess the IL-17A positive cells in CRSsNP and control. ELISA was used to detect the expression of MPO.
RESULT:CRSsNP had higher mRNA expression of RORC, IL-17A and IL-22 and increased protein expression of MPO. The mRNA expression of RORC, IL-17A and IL-22 was positively correlated with each other but none of them was correlated with the expression of MPO in CRSsNP and control.
CONCLUSION:Both Th17 and neutrophils contribute to the pathogenesis of CRSsNP, however, the neutrophil infiltration may not be recruited by Th17 cytokines.
