Expression and clinicopathological significance of foxM1 gene in laryngeal squamous cell carcinoma.
- Author:
Lizhu JIANG
1
;
Peng WANG
;
Hongyan CHEN
Author Information
1. Department of Otolaryngology, Dazu People's Hospital, Chongqing, 402360, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Forkhead Box Protein M1;
Forkhead Transcription Factors;
metabolism;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(19):897-900
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Forkhead Box M1 transcription factor (FoxM1) mRNA and protein in laryngeal squamous cell carcinoma (LSCC) and its clinical significance.
METHOD:Immunohistochemistry was used to examine the expression of FoxM1 in 89 LSCC tissues, 89 adjacent normal tissues and 20 laryngeal papilloma (LP) tissues. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to examine the expression of FoxM1 in 20 LSCC tissues, 20 LP tissues and 20 adjacent normal tissues. The relationship between FoxM1 expression and the clinicopathological parameters of LSCC were analyzed.
RESULT:FoxM1 mRNA and protein expression were gradually decreased from LSCC to LP and normal tissues. The difference was significant (P<0.05). There was a significantly correlation between FoxM1 and histologic differentiation, T stage, lymph node metastasis and clinical stage. Tumors with poorer differentiation, in higher T stage, with lymph node metastasis or in higher clinical stage presented higher FoxM1 expression than tumors with better differentiation, in lower T stage, without lymph node metastasis or in lower clinical stage (P<0.05). The positive expression of FoxM1 was not related with the age, gender or primary site of LSCC patients (P>0.05).
CONCLUSION:The up-regulation of FoxM1 may play an important role in the invasion and metastasis of LSCC.
