DNA methylation in thyroid carcinoma.
- Author:
Xianyun SONG
;
Xiaoling SHANG
;
Yutuo ZHANG
- Publication Type:Journal Article
- MeSH:
Chromatin;
DNA Methylation;
Epigenesis, Genetic;
Gene Expression;
Humans;
Neoplasm Metastasis;
Thyroid Neoplasms;
genetics
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(6):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Cancer has become clear that not merely gene variations but also epigenetic modifications may contribute to it. Epigenetic changes refer to stable alterations in gene expression with unrelated to changes in the underlying genetic sequence,resulting in heritable. DNA methylation is one of the common epigenetic changes. It control the gene expression through changing DNA conformation and stability, chromatin structer, DNA-protein interaction. The reversal of dysregulated DNA methylation has emerged as a potential strategy for the treatment of thyroid carcinoma. The artical will provide an overview of how DNA methylation contribute to thyroid carcinoma dissemination,invasion and metastasis and we will summarize the latest epigenetic therapies for thyroid carcinoma.
