Clinical efficacy analysis of adult sinonasal rhabdomyosarcoma.
- Author:
Yunlong BAI
;
Xiaohong CHEN
;
Yuyan YAN
;
Shurong ZHANG
;
Weiguo ZHOU
;
Jugao FANG
;
Zhigang HUANG
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Humans;
Lymphatic Metastasis;
Middle Aged;
Multivariate Analysis;
Paranasal Sinus Neoplasms;
diagnosis;
mortality;
pathology;
Prognosis;
Proportional Hazards Models;
Retrospective Studies;
Rhabdomyosarcoma;
diagnosis;
mortality;
pathology;
Survival Analysis;
Survival Rate;
Treatment Outcome;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(9):804-810
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical prognostic impact factors of adult sinonasal rhabdomyosarcoma (SNRMS).
METHOD:The clinical features, treatment methods, and disease outcome were reviewed retrospectively for twenty-three adult SNRMS between 2006 January and 2014 December. The survival analysis was performed by Kaplan-Meier estimate and the comparison between groups by Log-rank test. Multivariate analysis was carried out by Cox proportional hazard model.
RESULT:Patients' ages ranged from 18 to 59 years (median, 23.2 years). With a median follow-up of 20 moths (3-47 moths), 14 cases dead and 9 cases alive, the 1-year and 2-year overall survival (OS) rates were 77.1% and 35.0%, respectively. Within the 1-year and 2-year OS rates,early stage group had a higher overall survival rates than advanced diease group (100.0%, 66.7% and 83.3%, 10.5%, P < 0.05); combined therapy group had a higher overall survival rates than single treatment group (86.7%, 50.0% and 50.8%, 0, P < 0.05). In the non-metastasis group (21 cases), 1-year and 2-year distant metastasis rates were 38.1% and 70.5%, respectively. Multivariate analysis showed that radiotherapy, chemotherapy and tumor diameter less than 5 cm were good prognostic factors (P < 0.05), while the lymph node metastasis, meningeal involvement and orbital involvement were poor prognostic factors (P < 0 05). In the 14 cases of dead patients, 92 8% (13/14) died of distant metastasis.
CONCLUSION:Adult RMS had a high advanced rate with poor prognosis. Distant metastasis is the leading cause of death. Controlling distant metastasis is a key to improve the survival rate.
