The expression and clinical significance of hyaluronan synthase in nasal polyps.
- Author:
Shouhou LIU
;
Liang YU
;
Zhibiao LIU
- Publication Type:Journal Article
- MeSH:
Glucuronosyltransferase;
metabolism;
Humans;
Hyaluronan Synthases;
Hyaluronic Acid;
Immunohistochemistry;
Nasal Polyps;
enzymology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(12):1067-1070
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of hyaluronan synthasel-3 (HAS1-3) in nasal polyps, and discuss their clinical significance.
METHOD:The expression of HA, HAS1, HAS2 and HAS3 in nasal polyps group (25 cases) and inferior turbinate group (15 cases) was detected by immunohistochemistry and semi-quantitative RT-PCR.
RESULT:Compared with the control, the expression of HA, HAS1 and HAS3 was higher in nasal polyps (P<0. 05), while there was no significant difference in HAS2 expression (P>0. 05).
CONCLUSION:The increase of HASI and HAS3 expression may be the main cause of the excessive deposition of HA in nasal polyps, which may play an important role in the pathogenic process of nasal polyps, and become a potential target for therapy of nasal polyps.
