Expression level and significance of IL-17 and IL-23 in serum and nasal secretion of patients with allergic rhinitis and non-allergrie rhinitis.
- Author:
Guang YANG
;
Guoxi ZHENG
;
Luyao ZHANG
;
Kang ZHU
;
Wenjun XIN
;
Junrong WEI
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Humans;
Interleukin-17;
blood;
metabolism;
Interleukin-23;
blood;
metabolism;
Nasal Mucosa;
metabolism;
Rhinitis;
blood;
metabolism;
Rhinitis, Allergic;
blood;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(12):1086-1090
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of IL-17 and IL-23 in the pathogenesis of allergic rhinitis(AR) and non. allergic rhinitis(NAR).
METHOD:Selected 156 cases of patients with allergic rhinitis (AR group) and 59 cases of patients with non-allergic rhinitis (NAR group), 60 cases of healthy people (control group). All cases in AR group and NAR groups were evaluated by a visual analog scale (VAS) score of nasal symptoms. Collected peripheral blood and nasal secretions in all cases and then detected IL-17 and IL-23 expression levels.
RESULT:There was no significant difference in VAS score of AR group and NAR group (P>0. 05). IL-17 and IL-23 levels of serum and nasal secretions in AR group and NAR group were both higher than control group, with a highly significant difference (P <0. 05). The research showed a clear correlation between expression of IL-17 and IL-23 both in serum and nasal secretions of AR group and NAR(P<0. 05).
CONCLUSION:IL-17 and IL-23 may be important cytokines and IL-23/IL-17 pathway may play a significant role in the pathogenesis of allergic rhinitis and non-allergic rhinitis.
