The assessed value of 64 slice spiral CT perfusion imaging in laryngeal squamous cell carcinoma after chemotherapy and radiotherapy.
- Author:
Maosheng YAN
;
Xianming LI
;
Hang YIN
;
Dong WU
;
Dong YANG
;
Gang XU
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
diagnosis;
drug therapy;
radiotherapy;
Head and Neck Neoplasms;
diagnosis;
drug therapy;
radiotherapy;
Humans;
Laryngeal Neoplasms;
diagnosis;
drug therapy;
radiotherapy;
Perfusion Imaging;
Sensitivity and Specificity;
Squamous Cell Carcinoma of Head and Neck;
Tomography, Spiral Computed;
Tumor Burden
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(11):1002-1005
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the assessed value of 64 slice spiral CT perfusion imaging (CTPI) in laryngeal squamous cell carcinoma after chemotherapy and radiotherapy.
METHOD:Forty five patients diagnosed with local advanced laryngeal squamous cell carcinoma were selected. Conventional CT and CTPI were performed before treatment and at the time of radiation dose up to 40 Gy. Blood flow, blood volume, mean transit time and surface permeability were measured at the same time. According to the decrease of tumor volume in final examination, patients were divided into sensitive group and insensitive group. The tumor perfusion indexes were compared between groups.
RESULT:Blood flow, blood volume, surface permeability after 40Gy treatment were lower than before treatment in both sensitive group and the insensitive group ascended(P<0. 05). The AUC of ROC of blood flow, blood volume, mean transit time and surface permeability were 0. 804, 0. 843, 0. 852 and 0. 826. The sensitivity, specificity and accuracy of blood flow was 89. 7%, 86.8% and 90. 9%. There were 100. 0%, 91. 4% and 93. 7% in blood volume; 100. 0%, 67. 7% and 88. 3% in mean transit time; 91. 2%, 69. 4% and 90. 6% in surface permeability(P<0. 01).
CONCLUSION:Sixty-four slice spiral CT perfusion imaging is able to assess tumor status of laryngeal squamous cell carcinoma after chemotherapy and radiotherapy effectively.
