The expression and clinical significance of EphA2 and E-cadherin in papillary thyroid carcinoma.
- Author:
Yan LIU
;
Yuhua MIAO
;
Xiaoming LI
- Publication Type:Journal Article
- MeSH:
Adenoma;
metabolism;
pathology;
Antigens, CD;
Cadherins;
metabolism;
Carcinoma;
metabolism;
pathology;
Carcinoma, Papillary;
Humans;
Lymphatic Metastasis;
Receptor, EphA2;
metabolism;
Thyroid Cancer, Papillary;
Thyroid Gland;
metabolism;
Thyroid Neoplasms;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(11):1020-1023
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of EphA2 and E cadherin proteins in papillary thyroid carcinoma tissues, and to explore the relationship between them.
METHOD:Using immunohistochemical SP/PV method, we detected the expression of EphA2 and E cadherin in tumors of 43 papillary thyroid carcinomas, 11 thyroid adenoma and 10 normal thyroid tissues, then studied their relationships with clinic pathological factors.
RESULT:The total positive rates of EphA2 and E cadherin expression were 58. 14% and 32. 56% in papillary thyroid carcinoma tissues, 18. 18% and 81. 81% in thyroid adenoma.tissues and they were 10. 00% and 100. 00% in normal thyroid tissues respectively. The positive expression of EphA2 in carcinoma tissues was higher than in the thyroid adenoma tissues and normal thyroid tissues (P<0. 05) and the positive expression of E cadherin in carcinoma tissues was lower than that in the thyroid adenoma tissues and normal thyroid tissues (P<0. 05). The positive expression of EphA2 and E cadherin was associated with lymph node metastasis and histological grade (P<0. 05), but it was not associated with all the clinic-pathological factors including age, sex and the tumor size (P>0. 05). In papillary thyroid carcinoma tissues, the expression of EphA2 was negatively correlated with the expression of E cadherin protein (r= -0. 416, P<0. 01).
CONCLUSION:EphA2 and E cadherin may be involved in carcinogenesis and development of papillary thyroid carcinoma.
