The expression of Endophilin II and VEGF-C in human laryngeal cancer and connection with clinical treatment.
- Author:
Zhong Pu YIN
;
Chen YANG
- Publication Type:Journal Article
- MeSH:
Humans;
Immunohistochemistry;
Intracellular Signaling Peptides and Proteins;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Neoplasm Recurrence, Local;
Survival Rate;
Vascular Endothelial Growth Factor C;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(13):1156-1159
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of Endophilin II and VEGF-C in human Laryngeal cancer and its relationship with the clinical treatment effect.
METHOD:The expression and distribution of Endophilin II and VEGF-C protein were checked in 47 patients with laryngeal carcinoma in our hospital in 2006-09-2009-10 and 23 samples of normal tissues around the cancer by immunohistochemical staining SP method. After an appropriate surgical treatment, patients accepted a 5-year followup to evaluate their recurrence situation and 5-year survival rate.
RESULT:Immunohistochemistry showed that Endophilin II protein was strongly positive expressed in normal tissues around the cancer (positive rate 82.61%). And the expression level was dependent on the lymph metastasis, T stage and lymph invasion (P < 0.05). Patients with positive Endophilin II expression had a higher survival rate and better recurrence situation. Expression of VEGF-C was significantly higher in laryngeal carcinoma than in normal tissue around the cancer (positive rate 51.06% and 13.04%). the expression level was dependent on the lymph metastasis and lymph invasion (P < 0.05), and negatively correlated with recurrence and 5-year survival rate.
CONCLUSION:Endophilin II and VEGF-C may involve in laryngeal cancer, and the expression of Endophilin II and VEGF-C has a positive correlation with pathological features and lymph metastasis, and both are related with recurrence and 5-year survival rate. So these two proteins are likely to be a potential target for diagnosis and treatment of laryngeal cancer.
