Changes of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome before and after treatment of surgery.
- Author:
Shengguo WANG
1
;
Xianping SHI
1
;
Benzhong ZHOU
1
;
Longqiao LI
1
;
Jingtao BI
1
;
L V LING
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Humans;
Intraoperative Period;
Leptin;
blood;
Middle Aged;
Sleep Apnea, Obstructive;
blood;
surgery
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(18):1011-1013
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the change of serum leptin levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after surgery.
METHOD:The cases were divided into effective (n=44) and non-effective (n=13) groups according to PSG. The effective cases were divided into decreased (> or = 5%, n=25) and non-decreased(<5%, n=19) BMI. The level of serum leptin was detected by radioimmunoassay.
RESULT:The level of serum leptin after treatment (9.1 +/- 2.6 microg/L) was as high as before treatment (9.3 +/- 2.3 microg/L) in 13 non-effective cases. The level of serum leptin after treatment (7.15 +/- 1.23 microg/L) was significantly decreased than before treatment (12.79 +/- 2.98 microg/L) in 25 cases of decreased BMI (> or = 5%). The level of serum leptin after treatment (7.15 +/- 1.23 microg/L) was significantly decreased than before treatment (12.79 +/- 2.98 microg/L) in 19 cases of non-decreased BMI (<5%). Leptin level of all cases showed a positive correlation with AHI (P < 0.01).
CONCLUSION:The level of serum leptin in patients with OSAHS are increased. The serum leptin level of effective patients with OSAHS after treatment was significantly decreased. The level of serum leptin reflects the degree of AHI in patients with OSAHS.
