Role of Nods like receptors in the patients with nasal polyps.
- Author:
Shenhua ZHANG
1
;
Congxiang SHEN
1
;
Zhong WEN
1
;
Guanxue LI
1
;
Keke YANG
1
;
Xin SHI
1
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Carrier Proteins;
metabolism;
Case-Control Studies;
Female;
Humans;
Male;
Middle Aged;
NLR Family, Pyrin Domain-Containing 3 Protein;
Nasal Polyps;
metabolism;
pathology;
Nod1 Signaling Adaptor Protein;
metabolism;
Nod2 Signaling Adaptor Protein;
metabolism;
Receptors, Pattern Recognition;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(20):1118-1122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and role of a new pattern-recognition receptors (PRR), nucleotide binding oligomerization domain (Nod) like receptors (NLRs), in the patients with nasal polyps and nasal septum normal control group.
METHOD:The expressions of Nod1, Nod2 and Nalp3 mRNA and protein were explored with real-time RT-PCR, Western-Blot and immunohistochemistry respectively.
RESULT:The protein levels of Nod1, Nod2 and Nalp3 were expressed in nasal polyp and the control, but the expression of Nod1 and Nalp3 in nasal polyps were higher than those in control. No significant difference of Nod2 was seen between the two groups. And then, there was no significant difference of Nod1, Nod2, Nalp3 mRNA between two groups with Real-time RT-PCR.
CONCLUSION:The expression of Nod1 and Nalp3 are increased in nasal polyp tissues and maybe a etiological factors in the formation of nasal polyps.
