Correlation of VEGF expression with microvessel and microlymphatic density in sinonasal squamous cell carcinoma.
- Author:
Zhi TANG
1
;
Jin SUN
2
;
Jiqun WANG
3
;
Yulan LI
3
;
Yongming CHEN
3
;
Zhifeng TU
3
Author Information
1. Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China. damaodoctor@126.com
2. Department of Otolaryngology, First Affiliated Hospital of Zhengzhou University, China.
3. Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
blood supply;
metabolism;
pathology;
Female;
Humans;
Male;
Microvessels;
Nasal Cavity;
Neovascularization, Pathologic;
Nose Neoplasms;
blood supply;
metabolism;
pathology;
Paranasal Sinus Neoplasms;
blood supply;
metabolism;
pathology;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(20):1125-1128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density (MVD), microlymphatic vessel density (MLVD).
METHOD:The expression of VEGF, MVD and MLVD in 41 cases of sinonasal squamous cell carcinoma were detected by immunohistochemical technique.
RESULT:In the sinonasal squamous cell carcinoma, the positive rate of VEGF was 82.9% (34/41). The over expression of VEGF was related with tumor invasion, histological grading and lymphatic metastasis (P < 0.05). The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression (P < 0.05), but was not statistical difference in MLVD (P > 0.05).
CONCLUSION:VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors, but not promoting MLVD.
