Expression and significance of lymphocytes in chronic rhinosinusitis.
- Author:
Jing DU
1
;
Chuyuan ZHAO
1
;
Xin WANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
B-Lymphocytes;
cytology;
Case-Control Studies;
Child;
Chronic Disease;
Female;
Humans;
Male;
Middle Aged;
Nasal Polyps;
complications;
Rhinitis;
complications;
immunology;
Sinusitis;
complications;
immunology;
T-Lymphocyte Subsets;
cytology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(20):1106-1109
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the B lymphocytes(CD20) and T-lymphocyte subsets (CD4, CD8) expression and clinical significance in chronic rhinosinusitis.
METHOD:Immunohistochemical technique was applied to detect the expression of the B lymphocytes (CD20), helper T lymphocytes (CD4) and the cytotoxic T lymphocyte (CD8) in 15 patients with chronic rhinosinusitis without nasal polyps group (CRSsNP). 12 patients of chronic nasal sinusitis with nasal polyp (CRSwNP), 7 cases of recurrent CRSwNP group and 13 patients with inferior turbinate mucosa in the control group. The Mann-Whitney U test was used to analyze CD)20, CD4 and CD8 between the experimental groups and the control group. One- Way ANOVA was used to compare the lymphocyte infiltration between the experiment groups.
RESULT:Patients with CRS had higher infiltration of the B lymphocytes (CD20) and T lymphocyte subsets (CD4, CD88) than the patients of the control group (P < 0.05). The expression of T lymphocyte subsets (CD4, CD8) in CRSwNP and recurrent CRSwNP groups was significantly higher than in CRSsNP (P < 0.05). The expression of CD4 in the recurrent CRSwNP group was obviously higher than that in CRSsNP and CRSwNP (P < 0.01).
CONCLUSION:The B lymphocytes, helper T cells and cytotoxic T cells have the high expression in CRS groups, which involved with the formation of inflammation. Furthermore nasal polyps are closely related to T lymphocyte infiltration.
