Evaluation of the efficacy and safety of standardized dust mite allergen specific immunotherapy to children with allergic asthma.
- Author:
Weiwei SONG
;
Xiaoping LIN
;
Hua XIE
;
Ruonan CHAI
- Publication Type:Journal Article
- MeSH:
Adolescent;
Allergens;
therapeutic use;
Animals;
Antigens, Dermatophagoides;
therapeutic use;
Asthma;
immunology;
therapy;
Child;
Dust;
Female;
Humans;
Hypersensitivity;
immunology;
therapy;
Immunotherapy;
methods;
Male;
Pyroglyphidae;
immunology;
Safety;
Sensitivity and Specificity;
Skin Tests;
Vaccines;
therapeutic use
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(21):1193-1196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of mite allergen specific immunotherapy (SIT) in treating children with allergic asthma.
METHOD:A total of 136 patients with mite allergy were recruited into the study. They were randomly divided into two groups: SIT group (n = 66) and ST (symptomatic therapy) group (n = 70). They were investigated of SIT with standardized allergen vaccine or no SIT only symptomatic therapy respectively. Therapeutic evaluation index includes: asthma symptoms score, drug score, skin prick test, pulmonary function, serum specificity IgE (sIgE) and the new sensitization was also assessed. Local and systemic adverse reactions were used to evaluate the clinical safety.
RESULT:Clinical symptom scores, drug scores, Lung function, and skin test result all improved significantly after the treatment with SIT compared to ST group (P < 0.01). SIT groups do not have new sensitization and no fatal systemic reactions occurred.
CONCLUSION:The standardized dust mite allergen specific immunotherapy is efficacious and safe to Children with allergic asthma . SIT can reduce house dust mites skin sensitivity and prevent new allergen appeared.
