The association between genetic polymorphisms of DNA repair genes XPD, XPC and susceptibility to laryngeal carcinoma.
- Author:
Shenzhi TIAN
;
Qi XIAO
;
Jianguo ZHANG
;
Xiaoling YAN
;
Zhenping GUO
;
Fujin CHEN
;
Qiuli LI
;
Zhong GUAN
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
genetics;
Case-Control Studies;
DNA Repair;
genetics;
DNA-Binding Proteins;
genetics;
Female;
Genotype;
Humans;
Laryngeal Neoplasms;
genetics;
Male;
Polymorphism, Genetic;
Sequence Analysis, DNA;
Xeroderma Pigmentosum Group D Protein;
genetics
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(21):1199-1205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the association between genetic polymorphisms of DNA repair genes of XPD (751 Lys/Gln), XPC (PAT)and susceptibility to laryngeal carcinoma. To explore the effect between DNA repair genes of XPD (751 Lys/Gln), XPC (PAT) and carcinogenesis of LSCC(laryngeal squamous cell carcinoma).
METHOD:A case-control study was conducted involving 233 LSCC patients and 102 healthy controls to investigate the association between polymorphisms of XPD(751 Lys/Gln), XPC (PAT) and LSCC. All blood samples of the Han people from the Guang Dong Zone was analysze with methods of PCR, PCR-RFLP, ASA and the technique of checking DNA sequencing with sequenator. We explored the association between polymorphisms and the clinical pathologic characteristic of LSCC. The data was compute with SPSS13.0. Odds Ratios (ORs) with 95% CI for relevancy intensity were calculated using binary logistic regression analysis. REULT: There is no difference of the frequency of XPC-PAT and XPD (751 Lys/Gln) genotype between in LSCC and in healthy contradistinguish (P > 0.05).
CONCLUSION:There may be no association between the susceptibility to laryngeal carcinoma and the genotype of XPC-PAT and XPD (751 Lys/Gln).
