Study on the preventive effect of the gelomyrtol forte from secretory otitis media in patients with nasopharyngeal carcinoma after radiotherapy.
- Author:
Jian HE
1
;
Ping WU
;
Surina WU
;
Su Fu YU
;
Mi Ri Ka Mi LI
;
Lingfeng LIAO
;
Huatao QUAN
;
Shuai ZHANG
;
Yaoyun TANG
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma;
Drug Combinations;
Female;
Humans;
Male;
Middle Aged;
Monoterpenes;
therapeutic use;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
radiotherapy;
Otitis Media with Effusion;
etiology;
prevention & control;
Radiotherapy;
adverse effects
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(10):473-474
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observed the prevention efficacy of secretory otitis media after radiation therapy by the Myrtol Standardized Enteric Coated Soft Capsules.
METHOD:Sixty patients with nasopharyngeal carcinoma who Diagnosis without secretory otitis media before radiation therapy were divided into experimental group and control group, 30 cases in each group. After the start of radiation therapy ,the experimental group patients oral the Myrtol Standardized Enteric Coated Soft Capsules, each 0.3 g, 3 times a day, 7 days a course of treatment, oral the medication three months, the patients in the control group received no treatment. 3 months and 6 months after the end of radiation therapy, whether there is a difference comparison of experimental group and the control group in symptoms, signs, pure tone audiometry and tympanogram change.
RESULT:Seventeen patients (18 ears) (56.67%, 17/30) in the control group were suffering from secretory otitis media, 7 patients (7 ears) (23.33%, 7/30) in the experimental group were suffering from secretory otitis media. The difference between the two groups was statistically significant (P < 0.01). 17 patients (17 ears) in the control group and 7 patients (7 ears) in the experimental group were suffering from tinnitus. 20 patients(20 ears) in the control group and 9 patients (10 ears) in the experimental group have ear choking feeling. The difference between the two groups was statistically significant (P < 0.01). The air conduction hearing threshold of the experimental group before radiation therapy is (7.5 +/- 2.0) dB HL and the air conduction hearing threshold of the control group patients is (8.3 +/- 4.0) dB HL. The difference between the two groups was not statistically significant (P > 0.05). 3 months after radiation therapy,the gas conductive hearing threshold of the experimental group is (25.6 +/- 3.0) dB HL, but the data in the control group is (40.7 +/- 5.0) dB HL. The difference between the two groups was statistically significant (P < 0.01).
CONCLUSION:Patients with nasopharyngeal carcinoma oral the the Myrtol Standardized Enteric Coated Soft Capsules before radiation therapy can effectively reduce the incidence of secretory otitis media after radiotherapy, it can prevent the occurrence of secretory otitis media.
