Levels of serum IL-4, IFN-gamma, IL-32 in children with juvenile-onset recurrent respiratory papillomatosis.
- Author:
Benyu NAN
1
;
Bobei CHEN
;
Chuqin ZHANG
;
Minghua JIANG
;
Yuyao ZHANG
;
Haijie XIANG
;
Xiao YU
Author Information
1. Department of Otorhinolaryngology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325027, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Child;
Female;
Humans;
Infant;
Interferon-gamma;
blood;
Interleukin-4;
blood;
Interleukins;
blood;
Male;
Papillomavirus Infections;
blood;
Respiratory Tract Infections;
blood
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(12):651-653
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between serum IL-4, IFN-gamma, IL-10 levels and the aetiology of juvenile-onset recurrent respiratory papillomatosis.
METHOD:Serum IL-4, IFN-gamma, IL-32 levels of 15 JORRP children were detected by use of enzyme-linked immunosorbent assay (ELISA) and compared with those of healthy control group.
RESULT:Serum IL-4 levels were significantly higher in the JORRP children (P<0.01): (524.65 +/- 147.77)pg/ml in the JORRP children and (213.27 +/- 87.48) pg/ml in the healthy control group. Serum IFN-gamma levels were significantly lower in the JORRP children (P<0.01): (2.87 +/- 0.84) pg/ml in the JORRP children and (10.63 +/- 5.09) pg/ml in the healthy control group. Serum IL-32 levels were significantly lower in the JORRP children (P< 0.01): (2.47 +/- 1.60) pg/ml in the JORRP children and (9.08 +/- 2.66) pg/ml in the healthy control group.
CONCLUSION:1) While the concentration of Th2 like cytokine IL-4 in children with JORRP was higher than that in control group, the concentration of Th1 like cytokine IFN-gamma in children with JORRP was lower than that in controls, indicating that the polarization of Th1 /Th2 T cell in children with JORRP; 2) The polarization of Th1/Th2 T cell may cause the reduction of the serum IL-32 as a proinflammatory role in host immunity system that could not eradicate HPVs because of lacking enough inflammatory stimulation.
