The application of mitomycin C in treatment of airway scarring stenosis.
- Author:
Bin XIE
1
;
Min YIN
;
Xinjie ZHU
;
Ziping LIN
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
- Publication Type:Case Reports
- MeSH:
Adolescent;
Adult;
Child;
Cicatrix;
surgery;
Endoscopy;
methods;
Female;
Humans;
Laryngostenosis;
surgery;
Male;
Middle Aged;
Mitomycin;
therapeutic use;
Retrospective Studies;
Treatment Outcome;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(12):654-656
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the feasibility and efficacy of mitomycin C(MMC) in the treatment of airway scarring stenosis.
METHOD:The clinical materials of 11 patients with airway stenosis treated with MMC from 2008 to 2012 were analyzed retrospectively,including atresiaofnasopharynx/choanal atresia (2 cases), pharyngostenosis (1 case), and laryngotracheal stenosis (8 cases). All were treated with endoscopic surgery under general anesthesia. Patients received topical application of MMC (0.4 mg/ml) to the lesion for 5 minutes after the scar tissue removed and repeated five times.
RESULT:No patients occurred restenosis in 2 months' follow-up postoperative. Two patients with atresiaofnasopharynx/choanal atresia achieved satisfactory ventilation outcome, 8 patients with laryngotracheal stenosis decannulated successfully, 1 patients with pharyngostenosis achieved near normal deglutition.
CONCLUSION:MMC in endoscopic airway surgery is safe and effective in the treatment of airway stenosis and offers a high success rate for patients with grade 1-2 stenosis. It should be used as a first method in the treatment of airway stenosis.
