Correlation study between OPN, CD44v6, MMP-9 and distant metastasis in laryngeal squamous cell carcinoma.
- Author:
Lihua YANG
1
;
Xiaoling SHANG
;
Xiufang ZHAO
;
Yuanyuan LIN
;
Junchao LIU
Author Information
1. Hebei North University, Zhangjiakou, 075000, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Hyaluronan Receptors;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Matrix Metalloproteinase 9;
metabolism;
Middle Aged;
Neoplasm Metastasis;
Osteopontin;
metabolism;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(21):989-992
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of OPN, CD44v6 and MMP-9 in laryngeal squamous cell carcinomas (LSCC).
METHOD:The expression of OPN, CD44v6 and MMP-9 in the 47 cases of LSCC and 10 cases normal mucosa were detected by immunohistochemical method. The correlation between OPN, CD44v6 and MMP-9 proteins expressions and the correlation between them and clinicopathological feature were also studied.
RESULT:(1) The positive expression rates of OPN, CD44v6 and MMP-9 were 63.8%, 76.6% and 68.1% in LSCC of 47 cases and, and 10%, 30% and 0 in the tumor adjacent issue. (2) The positive rate of OPN and CD44v6 was significantly correlated with the clinical staging, the pathological grading and the metastasis of cervical lymph node (P < 0.05). The positive rate of MMP-9 was correlated with the clinical staging and the metastasis of cervical lymph node (P < 0.05). The positive rates of OPN, CD44v6 and MMP-9 were not correlated with patient's age, sex and tumor location (P > 0.05). (3) The expression of OPN was well correlated with the positive rate of CD44v6 and MMP-9 in LSCC (r = 0.421, P < 0.01, r = 0.340, P < 0.05). The expression of positive rate of CD44v6 and MMP-9 was well related in LSCC as well (r = 0.376, P < 0.01).
CONCLUSION:There is a high level of expression of OPN, CD44v6 and MMP-9 in LSCC. OPN, CD44v6 and MMP-9 are positively related and involved in the invasion and metastasis of LSCC.
