Intravitreal Triamcinolone Reinjection for Refractory Diabetic Macular Edema.
10.3341/kjo.2006.20.3.156
- Author:
Alireza RAMEZANI
1
;
Hamid AHMADIEH
;
Homa TABATABAEI
Author Information
1. Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arramezani@gmail.com
- Publication Type:Original Article ; Clinical Trial ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Diabetic macular edema;
Intravitreal triamcinolone;
Intraocular pressure;
Macular thickness;
Reinjection
- MeSH:
Vitreous Body;
Visual Acuity;
Triamcinolone/*administration & dosage;
Treatment Outcome;
Tomography, Optical Coherence;
Time Factors;
Retreatment;
Prospective Studies;
Male;
Macular Edema, Cystoid/*drug therapy/etiology/pathology;
Intraocular Pressure;
Injections;
Humans;
Glucocorticoids/*administration & dosage;
Follow-Up Studies;
Female;
Diabetic Retinopathy/*complications/pathology
- From:Korean Journal of Ophthalmology
2006;20(3):156-161
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema. METHODS: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired t test and were compared to the results of the first injections. RESULTS: Of all returning patients, 12 cases with complete records were considered candidates for reinjection. Visual acuity (VA) changes were not significant after the first and second interventions, although there was a relative improvement (0.14 logMAR) 2 months after the first injection. Reductions of central macular thickness (CMT) were 43+/-69 micrometer, and 40+/-69 micrometer after the first injection and 27+/-48 micrometer, 49+/-58 micrometer after the reinjection at 2 and 4 months, respectively. None of the mentioned changes was significant. After the second injection, however, intraocular pressure was elevated at both 2 and 4 months (3.6 and 2.4 mmHg respectively, P<0.05). Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P=0.001). CONCLUSIONS: The transient beneficial effects of IVT on diabetic macular edema are not repeated with second injections. However, IVT-related ocular hypertension is more persistent after reinjection.
