Transplanting neural stem cells in nerve conduit to promote rats facial nerve regeneration.
- Author:
Yong SHI
1
;
Liang ZHOU
;
Jie TIAN
;
Yang WANG
Author Information
1. Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Facial Nerve Injuries;
surgery;
Female;
Lactic Acid;
Nerve Regeneration;
Neural Stem Cells;
transplantation;
Polyglycolic Acid;
Polylactic Acid-Polyglycolic Acid Copolymer;
Pregnancy;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(22):1040-1042
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To construct a biodegradable PLGA nerve conduit (NC) filled with NSCs in order to improve facial nerve regeneration.
METHOD:SD rats were subjected to right facial nerve transection, and PLGA NCs filled with NSCs were used to bridge the nerve gap. Facial nerve regeneration was assessed 4 and 12 weeks after surgery, through electrophysiological testing, and morphometric analysis of axons.
RESULT:Nerve action potential amplitude, and axonal area were significantly greater in the NSCs group than the empty NC group.
CONCLUSION:NSCs transplantation may improve regeneration of the facial nerve.
