Transforming Growth Factor-beta Levels in Human Aqueous Humor of Glaucomatous, Diabetic and Uveitic Eyes.
10.3341/kjo.2006.20.3.162
- Author:
Seong Hee MIN
1
;
Tong Il LEE
;
Yun Seok CHUNG
;
Hwang Ki KIM
Author Information
1. Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea. eye1001@paran.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Aqueous humor;
Neovascular glaucoma;
Primary open angle glaucoma;
Secondary open angle glaucoma;
Transforming growth factor-beta
- MeSH:
Uveitis/*metabolism;
Transforming Growth Factor beta/*metabolism;
Severity of Illness Index;
Middle Aged;
Humans;
Glaucoma, Open-Angle/*metabolism;
Glaucoma, Angle-Closure/*metabolism;
Enzyme-Linked Immunosorbent Assay;
Diabetic Retinopathy/*metabolism;
Biological Markers/metabolism;
Aqueous Humor/*metabolism;
Aged, 80 and over;
Aged;
Adult
- From:Korean Journal of Ophthalmology
2006;20(3):162-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma. METHODS: The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method. RESULTS: The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG. CONCLUSIONS: These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.
