Th1/Th2 cytokines and its clinical significance in obstructive sleep apnea hypopnea syndrome children without allergic rhinitis and asthma.
- Author:
Jun SHI
1
;
Jingrong LV
;
Hao WU
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai,200092, China.
- Publication Type:Journal Article
- MeSH:
Asthma;
Case-Control Studies;
Child;
Child, Preschool;
Female;
Humans;
Infant;
Interferon-gamma;
blood;
Interleukin-4;
blood;
Interleukin-5;
blood;
Lymphotoxin-alpha;
blood;
Male;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
Sleep Apnea, Obstructive;
blood;
Th1 Cells;
metabolism;
Th2 Cells;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(23):1073-1076
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze Th1 and Th2 immune balance related cytokines and clinical significance in obstructive sleep apnea hypopnea syndrome children without allergic rhinitis and asthma.
METHOD:Collected 91 cases of obstructive sleep apnea hypopnea syndrome children with obstructive level data, and measured the serum Th1 cytokine TNF-beta and IFN-gamma, Th2 cytokines IL-4 and IL-5 levels. One hundred and five normal children were enrolled for the same detection of serum cytokines.
RESULT:Non-allergic rhinitis and asthma children serum levels of IFN-gamma was lower than control group children, the difference was statistically significant (P < 0. 01). Other cytokines (TNF-beta, IL-4 and IL-5) were no significant difference with the control group.
CONCLUSION:Th1 and Th2 immune response was imbalance in non-allergic rhinitis and asthma obstructive sleep apnea hypopnea syndrome children. The decline in Th1 cell-mediated protective immune response cells may cause disease.
