Research progress on role of chemokine receptor CCR3 signaling in allergic airway diseases.
- Author:
Yi XU
;
Yuehui LIU
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Hypersensitivity;
metabolism;
Receptors, CCR3;
metabolism;
Respiratory System;
metabolism;
Signal Transduction
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(23):1099-1101
- CountryChina
- Language:Chinese
-
Abstract:
Allergic airway diseases have been identified as chronic inflammatory diseases of respiratory membranes, characterized by infiltration of many inflammatory cells, especially eosinophils. The expression of CCR3 is abundant on the cell surface of eosinophils. Increased accumulation of CCR3-driven inflammatory cells is thought to favor the development of allergy. In this review, we survey the properties of CCR3 and its ligands and highlight the roles of CCR3 signaling in allergic airway diseases.
