Advances in cytokine immune mechanisms of allergic rhinitis.
- Author:
Qiang ZHANG
;
Jia XU
;
Yuru LI
- Publication Type:Journal Article
- MeSH:
Cytokines;
immunology;
Humans;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
immunology;
Th1 Cells;
immunology;
Th2 Cells;
immunology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(23):1102-1104
- CountryChina
- Language:Chinese
-
Abstract:
Allergic rhinitis is a common disease, which was released by the IgE-mediated atopic individuals exposed to allergens in the earlier researches. However, there are variety of immunocompetent cells and cytokines involved in the nasal mucosa immunologic mechanism in nowadays researches. The mechanism of AR is caused by the imbalance of the Th1/Th2, a kind of allergic inflammation who is characterized by the nasal Th2 immune response dominant. Th1 cells mainly produce of IFN-gamma (does not include IL-4 and IL-5), Th2 cells produce IL-4, IL-5, IL-9 and IL-13 (not including IFN-gamma). Recently it was found that regulatory T cells (T regulatory cells, Treg) and Th17 cell research played a crucial role in the occurrence of allergic inflammation.
