Changes in small airway function in rhinitis without asthma.
- Author:
Junfeng JI
;
Qiuping WANG
;
Yong ZHANG
;
Zhiyi WANG
;
Xu SHI
;
Weijie GUAN
;
Kunmin WU
;
Li XU
;
Wei CHEN
;
Fei XUE
;
Manjie JIANG
;
You CHENG
;
Tianyou WANG
;
Nanshan ZHONG
- Publication Type:Journal Article
- MeSH:
Asthma;
Case-Control Studies;
Humans;
Respiratory Function Tests;
Respiratory System;
physiopathology;
Rhinitis;
physiopathology;
Rhinitis, Allergic;
physiopathology;
Skin Tests
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(21):1864-1867
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Observe the changes of small airway function in patients with rhinitis but without asthma and/or lower airway symptoms.
METHOD:Between June 2008 and December 2012, we recruited 903 subjects, including 377 with allergic rhinitis (AR), 262 with non-allergic rhinitis (NAR) and 264 healthy subjects. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, pulmonary ventilation function test and bronchial challenge test.
RESULT:The indices of FEV1/FVC%, MEF25pred% and MMEFpred% were lower in AR group than in the control group (P < 0.05). The indices of FEV1/FVC, MMEFpred%, MEF25pred% and MEF50pred% were also lower in NAR group than in the control group (P < 0.05). According to the FVCpred% and FEV1pred%, there were no differences between rhinitis group and the control group (P > 0.05). The positive rate of airway hyperresponsiveness(AHR) in AR group and in NAR group was 12.2%, 6.1% respectively. Indices of small airway function were all lower in the AHR group than NAHR group in rhinitis.
CONCLUSION:Compared with healthy controls, small airway function in patients with rhinitis has apparent changes, part of rhinitis patients has AHR, and is associated with small airway function changes.
