Treatment of recurrent laryngeal papilloma by submucosal resection and the effect on prognosis.
- Author:
Huiying HU
;
Qingxiang ZHANG
;
Guoyan SUN
;
Zhenkun YU
- Publication Type:Journal Article
- MeSH:
Child;
DNA, Viral;
blood;
Human papillomavirus 11;
isolation & purification;
Human papillomavirus 6;
isolation & purification;
Humans;
Laryngeal Neoplasms;
diagnosis;
surgery;
Laryngoscopes;
Lasers, Gas;
Neoplasm Recurrence, Local;
Papilloma;
diagnosis;
surgery;
virology;
Papillomavirus Infections;
diagnosis;
surgery;
Postoperative Period;
Prognosis;
Respiratory Tract Infections;
diagnosis;
surgery
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(21):1873-1877
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the efficacy of submucosal resection by CO2 laser in the treatment of recurrent laryngeal papilloma and the effect on prognosis.
METHOD:A total of 11 patients diagnosed as recurrent laryngeal papilloma were included in this review. Papilloma was marked before operation and checked under fibro-laryngoscope. Papilloma was resected completely including the submucosal tissure with CO2 laser or microequipment. In widespread papilloma, false membrane in raw surface were cleared 7-10 days after operation. Surgical specimens (including membrane) were detected by routine pathology, HPV typing and immunohistochemical pathologic examination. The patients were checked once a month in the first 3 months after operation, and then once for every 3 months. Once the hoarseness and other symptoms aggravated or the disease was recurrent, the patients were treated immediately.
RESULT:HPV viral DNA was found in 10/11 cases, with HPV11 (7/11 cases) and HPV6 (3/11 cases). Cases with regards to follow-up, from 6 months to 1 year, 3 cases were followed up 1 year after operation, without recurrence. Five patients including 2 children were followed up 6 to 12 months after operation, without recurrence. Two children underwent 2 or 3 operations, were followed-up more than 6 months withouting recurrence.
CONCLUSION:Papilloma submucosal resection could decrease postoperative recurrence and is worth to be further investigated.
