Reconstruction of maxillary sinus superior wall fractures with calcium phosphate cement/recombinant human bonemorphogenetic protein 7 compound implanted material in rabbit.
- Author:
Qunhui ZHANG
;
Feng YU
;
Haoliang ZHANG
;
Huicheng GONG
;
Ying LIN
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Cements;
chemistry;
therapeutic use;
Bone Morphogenetic Protein 7;
therapeutic use;
Calcium Phosphates;
chemistry;
Disease Models, Animal;
Fractures, Bone;
pathology;
surgery;
Humans;
Maxillary Sinus;
pathology;
Osteogenesis;
Rabbits;
Random Allocation;
Recombinant Proteins;
therapeutic use
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(21):1890-1893
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the osteogenetic character and repairing maxillary sinus superior wall fractures capability of calcium phosphate cement (CPC) before and after combined with recombinant human bone morphogenetie protein-7(rhBMP-7).
METHOD:A 10 mmX5 mm bone defect in the maxillary sinus superior wall was induced by surgery in all 24 New Zealand white rabbits. These 24 rabbits were randomly divided into two groups. The defects were repaired with CPC group (n = 12) and CPC/rhBMP-7 group (n = 12). The osteogenesis of bone defect was monitored by gro'ss observation, histological examination, observation under scanning electron microscope and measurement of ALP activity at 6 and 12 weeks after the implantation.
RESULT:In group CPC,new bone was found to form slowly and little by little. In group CPC/rhBMP-7, however, new bone was observed to form early and massively. The ALP activity in group CPC showed significant statistical difference with that of group CPC/rhBMP-7 (P < 0.05).
CONCLUSION:The CPC/rhBMP-7 composite has osteoconductibility and osteoinductibility, comparing the use of CPC/rhBMP-7 with CPC for the repair of orbital fracture, the former show obvious advantage repairing ability in maxillary sinus superior wall defect.
