The expression and clinical significance of Bax and PHF20 in laryngeal squamous cell carcinoma.
- Author:
Chunming ZHANG
;
Wei GAO
;
Shubin DONG
;
Ganggang CHEN
;
Rui HAN
;
Shuxin WEN
;
Binquan WANG
- Publication Type:Journal Article
- MeSH:
Antigens, Neoplasm;
metabolism;
Biomarkers, Tumor;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
Head and Neck Neoplasms;
metabolism;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
metabolism;
Lymphatic Metastasis;
Prognosis;
Squamous Cell Carcinoma of Head and Neck;
bcl-2-Associated X Protein;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(19):1701-1705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Bax and PHF20 in laryngeal squamous cell carcinoma (LSCC)and to discuss their relevance and the roles in carcinogenesis and development in LSCC.
METHOD:The expressions of Bax and PHF20 in the LSCC tissues and normal mucosa tissues adjacent to carcinoma were detected by SP immunohistochemistry assay. The relationship between the expressions of Bax and PHF20 and the clinicopathological characteristics including clinical stage, pathological type, histological grade and lymph node metastasis in LSCC were analyzed according to the clinical data.
RESULT:(1) The expressions of Bax and PHF20 were both significantly lower in the LSCC tissue than that in the normal laryngeal tissue (P < 0.01). (2) In clinical stage grouping, there were no statistical differences of the quantity and positive rate of Bax and PHF20 expressions among supraglottic, glottic and subglottic LSCC (P > 0.05). In histological differentiation grouping, the quantity and positive rate of Bax and PHF20 expressions decreased significantly in poorly differentiated LSCC compared with the well and moderately differentiated LSCCs (P < 0.01, P < 0.05, respectively). In T stage grouping, the quantity and positive rate of Bax and PHF20 expressions were both significantly higher in T1 + T2 compared with T3 +T4 (both P < 0.01). In addition, the quantity and positive rate of Bax and PHF20 expressions were both significantly higher in LSCC with lymph node metastasis compared to that without lymph node metastasis (both P < 0.01).
CONCLUSION:The lack of Bax and PHF20 might contribute to the carcinogenesis and development in LSCC. The positive expression of Bax and PHF20 maybe relative to T term degree, differentiation degree and lymphamatic metastasis of LSCC.
