Expression of human ether-a-go-go-related gene in laryngeal carcinoma.
- Author:
Dashuai LIANG
;
Liping WANG
;
Wenyue JI
- Publication Type:Journal Article
- MeSH:
ERG1 Potassium Channel;
Ether-A-Go-Go Potassium Channels;
metabolism;
Humans;
Laryngeal Neoplasms;
metabolism;
RNA, Messenger
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(24):2160-2163
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of human ether-α-go-go-related gene (herg) and hERG protein expressed by the gene in laryngeal carcinoma compared with the control group(mucosa adjacent to cancer of 2 cm).
METHOD:Expression of herg and hERG protein was detected by immunohistochemistry (SP) and real-time PCR in resected tissue of laryngeal carcinoma and mucosa adjacent to cancer of 2 cm.
RESULT:(1) By immunohistochemistry, the positive expression rate of hERG in laryngeal carcinoma was 76.7% (23/30), while it was 10.0% (2/20) in mucosa adjacent to cancer of 2 cm, the difference between which was statistically significant (P < 0.05). (2) By real-time PCR, the expression level of herg mRNA in laryngeal carcinoma is 2.25 times higher than that in mucosa adjacent to cancer of 2 cm.
CONCLUSION:Herg is highly expressed in tissue of laryngeal carcinoma, and it may be have some relevance to the happening and development of laryngeal carcinoma.
