Effect of specific immunotherapy on GM-CSF and IL-5 in the tissues of recurrent nasal polyps.
- Author:
Jiefeng GUO
;
Jiacheng FENG
;
Lili LIN
;
Xiaoming ZHAO
;
Huiqing WU
- Publication Type:Journal Article
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Granulocyte-Macrophage Colony-Stimulating Factor;
metabolism;
Humans;
Immunotherapy;
Inflammation;
drug therapy;
Interleukin-5;
metabolism;
Nasal Mucosa;
pathology;
Nasal Polyps;
drug therapy;
metabolism;
Rhinitis, Allergic, Perennial;
drug therapy;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(23):2023-2025
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mechanism and clinical significance of specific immunotherapy (SIT) on the expression changes of GM-CSF and IL-5 in the tissue samples of recurrent nasal polyps.
METHOD:Perennial allergic rhinitis patients with recurrent nasal polyps were randomly divided into 2 groups. The experimental group of 19 patients was treated by SIT and standardized treatment (glucocorticoid nasal spray) , and the control group of 17 patients was only treated by standardized treatment (glucocorticoid nasal spray). We measured the expression levels of GM-CSF and IL-5 in the tissue samples of the nasal polyps by ELISA, and compared the results obtained before treatment with expression levels detected at 6 months and 1 year after the treatment.
RESULT:The expression of GM-CSF and IL-5 in the recurrent nasal polyps reduced significantly (P < 0.05) in both groups after 6 months and 1 year post-treatment compared with pre-treatment, and the expression of GM-CSF and IL-5 in the experimental group was much lower than that of the control group.
CONCLUSION:SIT decreases the expression of GM-CSF and IL-5 and reduces the inflammatory reaction in the tissue samples of recurrent nasal polyps.
