Relationship between vasculogenic mimicry and clinic pathological features in laryngeal carcinoma.
- Author:
Yan FENG
;
Binquan WANG
;
Gang LIANG
;
Shuxin WEN
;
Ruifang SUN
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
pathology;
Endothelium, Vascular;
pathology;
Head and Neck Neoplasms;
pathology;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
pathology;
Neoplasm Recurrence, Local;
Neovascularization, Pathologic;
Squamous Cell Carcinoma of Head and Neck
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(23):2071-2075
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the presence of vasculogenic mimicry in laryngeal squamous cell carcino- ma and explore its clinical significance.
METHOD:The presence of vasculogenic mimicry and expression of endotheli- um-dependent vessel in 138 laryngeal squamous cell carcinomas cases were detected by the immunohistochemistry and tissue microarray. Metlab software was used to evaluate the relationship among vasculogenic mimicry, mi- crovessel density and clinic pathological parameters in laryngeal carcinoma.
RESULT:We found vasculogenic mimicry in 32 (26.23%) of 122 laryngeal carcinoma samples. The mean of microvessel density is 12.61 per high-power field. The vasculogenic mimicry and expression of endothelium-dependent vessel were not significantly related to patient age or gender, tumor location, pathology grade, T stage or N stage (P > 0.05). However, the vasculo- genic mimicry and the mean of microvessel density were a little higher in patients older than 60, with poorly differ- entiated and patients with N₁₋₃ stage. Vasculogenic mimicry was positively correlatedwith microvessel density (r = 0.1927, P < 0.05).
CONCLUSION:Vasculogenic mimicry can occur in laryngeal carcinoma. Moreover, vasculogenic mimicry may be associated with recurrence and metastasis in laryngeal carcinoma.
