The progress study of tumor suppressor gene and apoptosis gene in nasal polyps.
- Author:
Dan CHEN
;
Lu CHEN
;
Ling XIAO
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Apoptosis Regulatory Proteins;
genetics;
Cytokines;
Disease Progression;
Genes, Tumor Suppressor;
Humans;
Nasal Mucosa;
Nasal Polyps;
genetics
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(23):2099-2102
- CountryChina
- Language:Chinese
-
Abstract:
Nasal polyps is a common disease in clinical, with nasal mucosal inflammatory hyperplasia. However, the molecular mechanism of it is largely unknown. Tumor suppressor genes, proliferation and apoptosis related genes and cytokines play an important role in the formation and pathological development of nasal polyps. The expression level of tumor suppressor related proteins and receptors is not constant, high level of these expression can stimulate nasal mucosal proliferation, while low or lacking expression may facilitate nasal polyps cells apoptosis. Both proliferation and apoptosis make a big difference in nasal polyps formation and development. This article concludes the relationships between new progressions in nasal polyps pathogenesis and tumor suppressor genes and proliferation apoptosis genes, which not only helps practitioners deeply and comprehensively understand nasall polyps pathogenesis but promotes explorations to effective therapeutics.
