Effect of H-uvulopalatopharyngoplasty on endothelium dependent flow-mediated dilation in patients with moderate to severe obstructive sleep apnea syndrome.
- Author:
Haibo YANG
1
;
Ying WANG
;
Mingmin DONG
Author Information
1. Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Endothelium, Vascular;
physiology;
Humans;
Otorhinolaryngologic Surgical Procedures;
methods;
Palate;
surgery;
Pharynx;
physiology;
surgery;
Polysomnography;
Prospective Studies;
Sleep Apnea, Obstructive;
surgery;
Uvula;
surgery
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(9):402-407
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:This study evaluates the effects of H-uvulopalatopharyngoplasty (H-UPPP) on endothelial function by endothelium dependent flow-mediated dilation(FMD) in patients with moderate to severe obstructive sleep apnea syndrome (OSAHS).
METHOD:Forty-five healthy subjects and 49 patients with moderately to severe OSAHS who desired H-UPPP were prospectively enrolled. FMD was measured by high-resolution B-mode ultrasonography. All subjects participated in sleep studies. These studies were repeated 6 months after H-UPPP in patients with moderately to severe OSAHS.
RESULT:There was significant difference in FMD between patients with moderately to severe OSAHS and healthy subjects at baseline (6.5 +/- 2.1)% vs (11.2 +/- 3.1)% (P < 0.01). FMD increased from (6.5 +/- 2.1)% to (9.7 +/- 2.7)% 6 months after H-UPPP in patients with moderately to severe OSAHS (P < 0.01).
CONCLUSION:FMD is decreased in patients with moderately to severe OSAHS, H-UPPP treatment of these patients leads to improvement of FMD.
